The regulation and function of neuronal and microglial SRY in pre-clinical models of Parkinson's disease

Sex differences in the brain affect the risk of neurological disorders. Women are more prone to depression and anxiety, whilst men have higher rates of Parkinson's disease (PD) and ADHD. Besides sex hormones, our research shows that the SRY gene on the Y-chromosome affects brain health in men. SRY is found in dopamine-producing neurons, controlling movement and dopamine levels. In PD models, SRY levels are abnormally high, and reducing SRY can protect male brains. My thesis explores SRY's interaction with dopamine receptors, its role in neurons and microglia, and its impact on PD progression. SRY in microglia promotes inflammation in males, suggesting that targeting SRY could be a new treatment strategy for male PD patients.