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Reason: Under embargo until February 2025. After this date a copy can be supplied under Section 51(2) of the Australian Copyright Act 1968 by submitting a document delivery request through your library

The potentiation of oxytetracycline via synergism with catechin

thesis
posted on 2022-02-23, 23:36 authored by NOORYASMIN BINTI ANWAR
Combinational therapy can be utilized to slow antibiotic resistance. The flavonoid catechin proves to enhance the efficacy of oxytetracycline against Staphylococcus aureus. The results obtained suggest that the mechanism underlying synergy does not exclusively include cellular damage, increased oxidative stress or intracellular antibiotic accumulation. However, the treatment of catechin is able to significantly reduce biofilm production in one of the two strains tested. Genomic analysis revealed a mutation in a calcium-dependent protein in the non-responsive strain resulting in a possible loss of function. These results suggest that integrative molecular approaches may aid in combating diseases in a pathogen-specific manner.

History

Principal supervisor

Joash Tan Ban Lee

Year of Award

2022

Department, School or Centre

School of Sciences (Monash University Malaysia)

Course

Master of Science (Research)

Degree Type

MASTERS

Faculty

Faculty of Science

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