Embargoed and Restricted Access
Reason: Under embargo until 30 June 2023. After this date a copy can be supplied under Section 51(2) of the Australian Copyright Act 1968 by submitting a document delivery request through your library.
The impact of stroke on gut permeability, motility, and immunity
A highly detrimental complication of stroke is peripheral infection. Recent experimental research suggested that the onset of lung infection after stroke occurs as a direct consequence of GI dysfunction. This experimental study assessed the impact of stroke on the epithelial population, enteric nervous system and immune system in its regulation of gut barrier leakiness and dysmotility. Elevated intestinal permeability was directly attributed to hyperactivation of the beta-adrenergic signalling pathway. There were selective modifications to the transcriptomes of epithelial cells and macrophages, as well as altered neuronal signalling that contribute to slowed gut transit at the point of post-stroke infection.
