Embargoed and Restricted Access
Reason: Under embargo until 30 October 2023. After this date a copy can be supplied under Section 51(2) of the Australian Copyright Act 1968 by submitting a document delivery request through your library.
The dynamic role of the bone marrow in B-Acute Lymphoblastic Leukaemia
thesis
posted on 2022-10-10, 03:23 authored by CLAIRE LOUISE PRITCHARDAcute lymphoblastic leukaemia (ALL) remains the most common childhood cancer with drug resistance continuing to plague patients. Leukaemic cells inhabit the bone marrow, influencing their surrounding environment to support disease expansion and resistance to therapeutic targeting. This thesis examines the location of ALL cells, describing new interactions between the leukaemic cells and the bone marrow that support disease progression. Continuing to investigate novel interactions between ALL cells and the bone marrow is critical for improving clinical treatments to eliminate drug resistant cells, minimising relapse.
