Monash University

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Reason: Under embargo until 24 November 2024. After this date a copy can be supplied under Section 51(2) of the Australian Copyright Act 1968 by submitting a document delivery request through your library

The communication between (epi)genetic and (epi)transcriptomic gene regulatory pathways for precise control of gene expression in embryonic stem cells

posted on 2023-11-23, 23:19 authored by VARUN KUMAR PANDEY
Genetic information flows from DNA to RNA (transcription) and RNA to protein (translation) – referred to as the ‘central dogma’ of molecular biology. ‘Epigenetic’ modification takes place on DNA and histones without changing the DNA sequences to control transcriptional output (DNA to RNA). While ‘epitranscriptomic/ RNA epigenetic’ modification happens in RNAs (at the post-transcriptional level) without altering the RNA sequences to control RNA turnover and translation. Although epigenetic and epitranscriptomic modifications act at different layers of gene regulation programs, recently, a handful of studies revealed the ‘crosstalk’ between these two pathways in controlling gene expression. However, the underlying mechanisms are not yet fully understood. This study establishes a link between the METTL3 and YTHDF2-mediated m6A epitranscriptomic pathway and the epigenetic pathway in gene regulation.


Principal supervisor

Partha Das

Year of Award


Department, School or Centre

Biomedical Sciences (Monash Biomedicine Discovery Institute)

Additional Institution or Organisation

Anatomy and Developmental Biology


Doctor of Philosophy

Degree Type



Faculty of Medicine, Nursing and Health Sciences