The Utility of Non-Invasive Fractional Flow Reserve Derived from Computed Tomography Coronary Angiography in the Diagnosis and Management of Coronary Artery Disease

This thesis investigates the feasibility of techniques to measure coronary blood flow using cardiac CT (CT-FFR). It identifies that CT-FFR is an accurate measure of coronary blood flow compared to the gold standard obtained during invasive coronary angiography. In patients with coronary artery disease, an abnormal CT-FFR result identified those at risk of future adverse events and a normal CT-FFR result conferred an excellent long-term prognosis. The use of cardiac CT to quantify the amount of heart muscle with impaired blood flow and the use of artificial intelligence may improve the utility and translation of CT-FFR techniques into clinical practice.