The Use of Sulfonyl Fluorides in PET Radiochemistry

This thesis developed a fluorine-18 radiolabelled molecule that can be attached to biomolecules under mild experimental conditions. The radiolabelled biomolecules were found to be unstable in biological systems and could not be used for imaging. This inherent instability was subsequently exploited to provide sources of fluorine-18 suitable for transport and use in remote nuclear medicine locations. This new method is highly efficient and will potentially benefit the patients undergoing diagnostic imaging.