Monash University

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Reason: Under embargo until 30 April 2024. After this date a copy can be supplied under Section 51(2) of the Australian Copyright Act 1968 by submitting a document delivery request through your library

The Therapeutic Targeting of Paediatric High-Grade Gliomas

posted on 2023-04-18, 03:12 authored by Dasun L. B. Fernando
Paediatric high-grade gliomas (pHGGs) are a deadly cancer of the brain which affects a very small group of the youngest and most vulnerable members of society. While many cancers have seen improvements in overall survival, this has not been the case for pHGGs. The research outlined within this thesis has investigated different strategies to combat this deadly disease by targeting disease specific features identified in cell lines isolated from pHGGs. The outcomes revealed ways of improving the effectiveness of treatment and overcoming treatment resistant features common in pHGGs to allow these patients the opportunity of living a disease-free life.


Principal supervisor

Bryan Williams

Additional supervisor 1

Afsar Ahmed

Additional supervisor 2

Paul Daniel

Year of Award


Department, School or Centre

Molecular and Translational Sciences

Additional Institution or Organisation

Hudson Institute of Medical Research, Monash Medical Centre

Campus location



Doctor of Philosophy

Degree Type



Faculty of Medicine, Nursing and Health Sciences