Monash University

Restricted Access

Reason: Restricted by author. A copy can be supplied under Section 51(2) of the Australian Copyright Act 1968 by submitting a document delivery request through your library.

The Role of pH and Proton Sensor GPR65 in Inflammation

posted on 2023-06-15, 01:42 authored by LIANG XIE
pH is a critical environmental factor influencing human physiology. This doctorate thesis explores how pH modulates inflammation through a proton-sensor GPR65. It identifies that a genetic variant impairing GPR65 signalling increases risks of atopic dermatitis and high blood pressure. It further reveals that acidic skin pH and signalling of a proton-sensor, GPR65, suppress the onset of atopic dermatitis, a cutaneous inflammatory disease and that acidic colonic pH and GPR65 signalling mediate the protection by dietary fibre against high blood pressure, where inflammatory responses play a causal role. It also demonstrates the immune mechanisms underlying these discoveries.


Principal supervisor

Charles Reay Mackay

Additional supervisor 1

Remy Robert

Additional supervisor 2

Francine Marques

Year of Award


Department, School or Centre

Biomedical Sciences (Monash Biomedicine Discovery Institute)

Additional Institution or Organisation


Campus location



Doctor of Philosophy

Degree Type



Faculty of Medicine, Nursing and Health Sciences