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The Role of Y Chromosome Lineage and COX Inhibition in Immune-Mediated Hypertension and Vascular Dysfunction

thesis
posted on 09.07.2017, 23:07 by SHANZANA ISLAM KHAN
Using a unique genetic model, we explored the role of Y chromosome lineage in blood pressure regulation and vascular function. We found that replacement of the Y chromosome of a hypertensive rat with that of a normotensive rat improved vascular function through reducing vascular immune cell infiltration. These infiltrating immune cells were found to impair vascular function through inducing the release of contractile cyclo-oxygenase (COX) factors from vessels. Interestingly however, systemic COX inhibition with aspirin treatment in hypertensive rats worsened immune cell infiltration, indicating the local vascular effects of COX inhibition are different to the effects of systemic COX inhibition.

History

Principal supervisor

Jaye Chin-Dusting

Year of Award

2017

Department, School or Centre

Pharmacology

Campus location

Australia

Course

Doctor of Philosophy

Degree Type

Doctorate

Faculty

Faculty of Medicine Nursing and Health Sciences

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