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The Role of MHCI Quality and Quantity in Determining CD8 T cell Development, Survival and Function

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thesis
posted on 06.04.2020 by YI XIONG SNG
The major histocompatibility complex class I (MHCI) molecule is essential for the development, homeostatic maintenance and activation of CD8 T cells. While it is clear that MHCI molecules are crucial in these processes, it is not clear how the similarities and differences between MHCI molecules and gene dosage influences the resulting CD8 T cell population. This thesis provides a deeper understanding of how the quality and quantity of MHCI affects 1) alloreactive CD8 T cell selection, 2) homeostatic maintenance of peripheral naive CD8 T cells and 3) CD8 T cell activation during infection.

History

Principal supervisor

Nicole La Gruta

Additional supervisor 1

Kylie Quinn

Additional supervisor 2

Stephen Daley

Year of Award

2020

Department, School or Centre

Biochemistry and Molecular Biology

Additional Institution or Organisation

Biomedicine Discovery Institute

Campus location

Australia

Course

Doctor of Philosophy

Degree Type

DOCTORATE

Exports

Exports