Monash University
02_PhD_Thesis_Final_Amendments_without_signatures.pdf (8.38 MB)

The Role of MHCI Quality and Quantity in Determining CD8 T cell Development, Survival and Function

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posted on 2020-04-06, 22:17 authored by YI XIONG SNG
The major histocompatibility complex class I (MHCI) molecule is essential for the development, homeostatic maintenance and activation of CD8 T cells. While it is clear that MHCI molecules are crucial in these processes, it is not clear how the similarities and differences between MHCI molecules and gene dosage influences the resulting CD8 T cell population. This thesis provides a deeper understanding of how the quality and quantity of MHCI affects 1) alloreactive CD8 T cell selection, 2) homeostatic maintenance of peripheral naive CD8 T cells and 3) CD8 T cell activation during infection.


Principal supervisor

Nicole La Gruta

Additional supervisor 1

Kylie Quinn

Additional supervisor 2

Stephen Daley

Year of Award


Department, School or Centre

Biochemistry and Molecular Biology

Additional Institution or Organisation

Biomedicine Discovery Institute

Campus location



Doctor of Philosophy

Degree Type



Faculty of Medicine, Nursing and Health Sciences