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The Role of Integrin-Linked Kinase (ILK) in Acute Myeloid Leukaemia

thesis
posted on 03.09.2019, 05:12 by MOHAMMED IBRAHIM A ALASSEIRI
Acute myeloid leukaemia is an aggressive blood cancer. Unfortunately, around 75% of AML patients who receive intensive chemotherapy experience a relapse within 2 years of remission. Integrin-linked kinase (ILK) is overexpressed in many human cancers. However, its function in AML is yet to be determined. In this study, I demonstrated that ILK inhibition decreased AML cell proliferation and survival. In addition, I show a novel role for ILK in promoting AML cell survival. Moreover, ILK inhibition sensitises AML cells to other targeted therapies. Overall, these findings suggest that blocking ILK could eliminate AML cells and overcome resistance to therapy.

History

Principal supervisor

Bryan Williams

Additional supervisor 1

Afsar Ahmed

Year of Award

2019

Department, School or Centre

Molecular and Translational Sciences

Additional Institution or Organisation

Hudson Institute for Medical Research

Campus location

Australia

Course

Doctor of Philosophy

Degree Type

DOCTORATE

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