Monash University

Embargoed and Restricted Access

Reason: Under embargo until August 2020. After this date a copy can be supplied under Section 51(2) of the Australian Copyright Act 1968 by submitting a document delivery request through your library

The Role of Integrin-Linked Kinase (ILK) in Acute Myeloid Leukaemia

posted on 2019-09-03, 05:12 authored by MOHAMMED IBRAHIM A ALASSEIRI
Acute myeloid leukaemia is an aggressive blood cancer. Unfortunately, around 75% of AML patients who receive intensive chemotherapy experience a relapse within 2 years of remission. Integrin-linked kinase (ILK) is overexpressed in many human cancers. However, its function in AML is yet to be determined. In this study, I demonstrated that ILK inhibition decreased AML cell proliferation and survival. In addition, I show a novel role for ILK in promoting AML cell survival. Moreover, ILK inhibition sensitises AML cells to other targeted therapies. Overall, these findings suggest that blocking ILK could eliminate AML cells and overcome resistance to therapy.


Principal supervisor

Bryan Williams

Additional supervisor 1

Afsar Ahmed

Year of Award


Department, School or Centre

Central Clinical School

Additional Institution or Organisation

Molecular and Translational Science (Hudson Institute)

Campus location



Doctor of Philosophy

Degree Type



Faculty of Medicine, Nursing and Health Sciences