Reason: Under embargo until August 2020. After this date a copy can be supplied under Section 51(2) of the Australian Copyright Act 1968 by submitting a document delivery request through your library
The Role of Integrin-Linked Kinase (ILK) in Acute Myeloid Leukaemia
thesis
posted on 2019-09-03, 05:12authored byMOHAMMED IBRAHIM A ALASSEIRI
Acute myeloid leukaemia is an aggressive blood cancer. Unfortunately, around 75% of AML patients who receive intensive chemotherapy experience a relapse within 2 years of remission. Integrin-linked kinase (ILK) is overexpressed in many human cancers. However, its function in AML is yet to be determined. In this study, I demonstrated that ILK inhibition decreased AML cell proliferation and survival. In addition, I show a novel role for ILK in promoting AML cell survival. Moreover, ILK inhibition sensitises AML cells to other targeted therapies. Overall, these findings suggest that blocking ILK could eliminate AML cells and overcome resistance to therapy.
History
Principal supervisor
Bryan Williams
Additional supervisor 1
Afsar Ahmed
Year of Award
2019
Department, School or Centre
Central Clinical School
Additional Institution or Organisation
Molecular and Translational Science (Hudson Institute)