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The Role of Inflammasome-Associated Innate Immune Receptors in Gastric Cancer

thesis
posted on 2023-05-21, 22:59 authored by ALICE JANET WEST
Gastric cancer is one of the deadliest types of cancer, with minimal development of effective therapeutics for patients in the past decade. Several factors influence the development of gastric cancer, including inflammation and local immune responses at the site of the cancer. This thesis identifies innate immune regulators that mediate the initiation and progression of gastric cancer controlled through a multiprotein complex termed an inflammasome. These findings may be used to develop novel targets for diagnostics, prognostics and potentially druggable targets.

History

Principal supervisor

Brendan Jenkins

Additional supervisor 1

Ashley Mansell

Year of Award

2023

Department, School or Centre

Molecular and Translational Sciences

Additional Institution or Organisation

Hudson Institute of Medical Research

Campus location

Australia

Course

Doctor of Philosophy

Degree Type

DOCTORATE

Faculty

Faculty of Medicine, Nursing and Health Sciences