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The Role of Gut Microbial Metabolites in Alzheimer’s Disease
thesis
posted on 2022-02-16, 06:13 authored by YICHEN ZHOUShort chain fatty acids (SCFAs) are the key microbial metabolites produced by bacterial fermentation of dietary fiber, however, the role of SCFAs in Alzheimer’s disease (AD) is unclear. In our study, we subjected 5xFAD mice, a mouse model for AD, to specialized diets releasing different amounts of SCFAs in the colon. We found that lack of SCFAs accelerated a memory deficit, whereas SCFA supplementation delayed onset of cognitive decline. Furthermore, SCFA intake impacted microglial function, neurogenesis, immune cell profile in the brain. Altogether, our findings show the promise of SCFAs in the prevention of AD.
