Hattapark Dejakaisaya Thesis_Final_Submission.pdf (17.2 MB)
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The Role of Glutamate in the Pathogenesis of Acquired Epilepsy in Alzheimer’s Disease

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thesis
posted on 09.01.2022, 12:08 by HATTAPARK DEJAKAISAYA
Alzheimer’s disease (AD) patient has up to 10-fold higher risk of developing epilepsy compared to healthy controls. However, the mechanism that links AD pathologies to epileptic seizures is not elucidated. Disruption to glutamate-glutamine cycle in the brain caused by AD has the potential to enhance this risk. I found that the amount of key components in the glutamate-glutamine cycle, such as GLT-1, were altered in the seizure-prone mouse model of AD. Also, pharmacologically enhancing GLT-1 level reduced the seizure severity in the same model. Thus, disruption to glutamate-glutamine cycle can be one of the links between AD and epilepsy.

History

Principal supervisor

Patrick Kwan

Additional supervisor 1

Nigel Jones

Year of Award

2022

Department, School or Centre

Neuroscience

Campus location

Australia

Course

Doctor of Philosophy

Degree Type

DOCTORATE

Faculty

Faculty of Medicine, Nursing and Health Sciences

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