Monash University
Thesis amended_Nicole Chew.pdf (13.29 MB)

The Role of Fibroblast Growth Factor Receptors in Cancer

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posted on 2021-04-08, 05:12 authored by NICOLE JING SIAN CHEW
Breast cancer accounts for a quarter of all cancers and ranks as the second most common cancer in the world. In particular, triple negative breast cancer is aggressive and lacks targeted therapeutic options. Hence, new therapeutic targets need to be identified for personalised treatment strategies to improve patient outcomes. My PhD work describes abnormal fibroblast growth factor receptors (FGFRs) as therapeutic targets in breast cancer. It investigates two FGFR fusions, including the identification of a novel FGFR fusion, and the identification of novel targeted combinations involving FGFR. The findings in my PhD support targeting FGFRs as a precision medicine approach for specific cancers.


Principal supervisor

Roger Daly

Additional supervisor 1

Rachel Lee

Year of Award


Department, School or Centre

Biomedical Sciences (Monash Biomedicine Discovery Institute)

Additional Institution or Organisation

Biochemistry and Molecular Biology

Campus location



Doctor of Philosophy

Degree Type



Faculty of Medicine, Nursing and Health Sciences