Monash University
Bassam Kashgari - PhD thesis.pdf (5.49 MB)

The Role of ASC Inflammasomes in Pancreatic Cancer

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posted on 2023-01-10, 22:14 authored by BASSAM FAWAZ A KASHGARI
Pancreatic ductal adenocarcinoma (PDAC) is an aggressive and highly lethal malignancy.The dysregulation of the immune system plays a role in the progression of the disease. Inflammasomes are key regulators of innate immunity in chronic inflammatory disorders and autoimmune diseases, but their role in PDAC remains ill-defined. The findings in this work show that elevated ASC levels are a key feature of PDAC and supports the role of ASC as a tumor promoter in PDAC through mediating IL-18 rather than IL-1β. Understanding the currently ill-defined role of ASC inflammasomes in PDAC may provide novel biomarkers and druggable candidates for targeted therapy for PDAC patients.


Principal supervisor

Brendan Jenkins

Additional supervisor 1

Daniel Croagh

Year of Award


Department, School or Centre

Molecular and Translational Sciences

Additional Institution or Organisation

Hudson Institute of Medical Research

Campus location



Doctor of Philosophy

Degree Type



Faculty of Medicine, Nursing and Health Sciences