Monash University

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Reason: Under embargo until December 2021. After this date a copy can be supplied under Section 51(2) of the Australian Copyright Act 1968 by submitting a document delivery request through your library

The Role of ABCA12 in Type 2 Diabetes

posted on 2018-12-03, 05:34 authored by GLORIA MARIA ANGELA URSINO
Diabetes is a widespread metabolic disease that occurs when the body cannot control its blood glucose concentration due to dysfunction or absence of pancreatic β-cells. This thesis examines the role of the lipid transporter ABCA12 in β-cells. β-cells secrete insulin to lower blood glucose concentration, and their function is important for the prevention of diabetes. Using a genetically engineered mouse lacking ABCA12 specifically in the β-cell, I uncovered how loss of this protein affects the organisation of cholesterol to control insulin granule morphology and secretion, as well as how it controls the levels of potentially toxic lipid species in β-cells.


Principal supervisor

Ian Macleod Smyth

Year of Award


Department, School or Centre

Biochemistry and Molecular Biology

Campus location



Doctor of Philosophy

Degree Type



Faculty of Medicine Nursing and Health Sciences