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The Role of ABCA12 in Type 2 Diabetes

thesis
posted on 03.12.2018 by GLORIA MARIA ANGELA URSINO
Diabetes is a widespread metabolic disease that occurs when the body cannot control its blood glucose concentration due to dysfunction or absence of pancreatic β-cells. This thesis examines the role of the lipid transporter ABCA12 in β-cells. β-cells secrete insulin to lower blood glucose concentration, and their function is important for the prevention of diabetes. Using a genetically engineered mouse lacking ABCA12 specifically in the β-cell, I uncovered how loss of this protein affects the organisation of cholesterol to control insulin granule morphology and secretion, as well as how it controls the levels of potentially toxic lipid species in β-cells.

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History

Principal supervisor

Ian Macleod Smyth

Year of Award

2018

Department, School or Centre

Biochemistry and Molecular Biology

Campus location

Australia

Course

Doctor of Philosophy

Degree Type

DOCTORATE

Faculty

Faculty of Medicine Nursing and Health Sciences

Exports

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Exports