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Reason: Under embargo until 31 January 2023. After this date a copy can be supplied under Section 51(2) of the Australian Copyright Act 1968 by submitting a document delivery request through your library, or by emailing document.delivery@monash.edu

The Prebiotic Role of Polyphenols and the Modulation of Gut Microbiota and Metabolic Parameters by Geraniin and its Enriched Extract in Animal Model

thesis
posted on 16.02.2022, 22:25 authored by MOHANAMBAL MOORTHY
Geraniin is a natural compound present abundantly in the rambutan rind and has the potential to ameliorate diet-induced metabolic syndrome. This study was carried out to identify whether geraniin's interaction with gut microbiota is the main mechanism for its efficacy against metabolic syndrome. Male Sprague Dawley rats were treated with various doses of geraniin and an enriched extract of geraniin (GEE). We observed that 5mg geraniin and 115mg GEE supplementation significantly improved diet-induced metabolic aberrations while increasing the relative abundance of a few butyrate-producing bacteria and plasma butyrate. These findings suggest that geraniin and its enriched extract are promising therapeutic agents against diet-induced metabolic syndrome.

History

Principal supervisor

Uma Palanisamy

Additional supervisor 1

Khalid Abdul Kadir

Additional supervisor 2

Wee Wei Yee

Year of Award

2022

Department, School or Centre

Jeffrey Cheah School of Medicine and Health Sciences (Monash University Malaysia)

Campus location

Malaysia

Course

Doctor of Philosophy

Degree Type

DOCTORATE

Faculty

Faculty of Medicine, Nursing and Health Sciences