The Kinetic and Dynamic Regulation of Calcitonin Gene Related Peptide (CGRP) Family Receptors

Calcitonin gene-related peptide (CGRP) receptors (R) are G protein coupled receptors that communicate information across the cell membrane to mediate physiological functions. CGRP family receptors are an important class of receptor; involved in migraine, cardiovascular diseases and inflammation, and consist of two proteins, a receptor activity modifying protein (RAMP) and a GPCR (CLR). However, few drugs are approved to act at the CGRP family receptors. These receptors are dynamic and to understand how they work, we need to be able to visualise these dynamics and how that relates to cellular signalling. The project combines multidisciplinary approaches to mechanistic understanding of how RAMPs and CGRP family agonists modulate CLR to fine-tune cellular responses.