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The JNK signalling pathway in renal ischaemia reperfusion injury
thesisposted on 03.09.2019, 05:12 by KEREN GRYNBERG
Acute kidney injury (AKI) is a serious condition which can be anticipated in situations like cardiac surgery. This thesis identifies the JNK1 enzyme as a key driver of cell death and inflammation in acute kidney injury. Pre-clinical studies showing protection with pharmacological JNK inhibition raise the potential for clinical trials.