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The Interplay of Cytokines in the Pathogenesis of Female Reproductive Cancer

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thesis
posted on 03.09.2019 by IRENE PAPAGEORGIOU
This thesis sought to examine the interplay of key molecular processes involved in the pathogenesis of cancer. Ground-breaking re-emergence of Nodal/Cripto was detected in endometrial cancer patient samples compared to healthy controls. Interestingly blockade of Nodal/Cripto activities, using monoclonal antibody treatment significantly reversed the carcinogenic behaviour of cellular models. This thesis also examined another molecule, with important functions within the female reproductive tract, the Interferon Epsilon. It was demonstrated that Interferon Epsilon treatment of aggressive endometrial cancer cells dramatically reduced cell growth. These findings could be utilized in the potential development of novel therapeutic agents for endometrial cancer.

History

Principal supervisor

Paul Hertzog

Additional supervisor 1

Nollaig Bourke

Year of Award

2019

Department, School or Centre

Molecular and Translational Sciences

Additional Institution or Organisation

Hudson Institute of Medical Research

Campus location

Australia

Course

Doctor of Philosophy

Degree Type

DOCTORATE

Exports

Exports