The Interaction Between Traumatic Brain Injury And Peripheral Trauma: Implications In Polytrauma And Heterotopic Ossification

Traumatic brain injury (TBI) and musculoskeletal (MSK) injuries are common in patients with multiple trauma. Despite initial findings showing that these injuries can influence each other, there is still a poor understanding of the underlying mechanism. This thesis examines the influence of MSK injuries on TBI biological markers and functional outcomes such as chronic pain. Next, the focus shifts to heterotopic ossification (HO), a condition characterised by the abnormal formation of bone. Finally, this thesis examines the influence of MSK and MSK+TBI on HO-related outcomes.