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The Fate of Mitochondria During Apoptosis

thesis
posted on 21.10.2021, 05:00 by TAHNEE LEONA SARAH SAUNDERS
Every day, millions of cells undergo programmed cell-death in our bodies; best known as apoptosis. During apoptosis, an organelle inside the cell, the mitochondria, becomes catastrophically damaged and DNA inside the mitochondria leaks out into the cell. If apoptosis is not functioning appropriately, the leaked mitochondrial DNA is mistakenly sensed as ‘non-self’, and the dying cell behaves as though it is virally infected; generating inflammatory signals and triggering an immune response. This thesis reports a newly defined response to apoptotic mitochondrial damage – called apoptotic mitophagy – and presents a novel phenomenon which may function to restrain mtDNA-induced inflammation during cell death.

History

Principal supervisor

Dominic Denardo

Additional supervisor 1

Kate McArthur

Additional supervisor 2

Benjamin T. Kile

Additional supervisor 3

Michael T. Ryan

Year of Award

2021

Department, School or Centre

Anatomy and Developmental Biology

Additional Institution or Organisation

Monash Biomedicine Discovery Institute

Campus location

Australia

Course

Doctor of Philosophy

Degree Type

DOCTORATE

Faculty

Faculty of Medicine, Nursing and Health Sciences

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