Monash University

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Reason: Under embargo until September 2022. After this date a copy can be supplied under Section 51(2) of the Australian Copyright Act 1968 by submitting a document delivery request through your library

The Fate of Mitochondria During Apoptosis

posted on 2021-10-21, 05:00 authored by TAHNEE LEONA SARAH SAUNDERS
Every day, millions of cells undergo programmed cell-death in our bodies; best known as apoptosis. During apoptosis, an organelle inside the cell, the mitochondria, becomes catastrophically damaged and DNA inside the mitochondria leaks out into the cell. If apoptosis is not functioning appropriately, the leaked mitochondrial DNA is mistakenly sensed as ‘non-self’, and the dying cell behaves as though it is virally infected; generating inflammatory signals and triggering an immune response. This thesis reports a newly defined response to apoptotic mitochondrial damage – called apoptotic mitophagy – and presents a novel phenomenon which may function to restrain mtDNA-induced inflammation during cell death.


Principal supervisor

Dominic Denardo

Additional supervisor 1

Kate McArthur

Additional supervisor 2

Benjamin T. Kile

Additional supervisor 3

Michael T. Ryan

Year of Award


Department, School or Centre

Biomedical Sciences (Monash Biomedicine Discovery Institute)

Additional Institution or Organisation

Anatomy and Developmental Biology

Campus location



Doctor of Philosophy

Degree Type



Faculty of Medicine, Nursing and Health Sciences