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The Epigenetic Control of Mitochondrial DNA Copy Number in Tumorigenesis and Differentiation

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thesis
posted on 24.09.2018 by XIN SUN
This thesis focuses on how the communication between the two genomes within a cell, namely the nuclear and mitochondrial genomes, is disrupted in cancer. It identifies abnormal levels in modifications to both genomes, as determined by the levels of DNA methylation, which regulate the number of mitochondrial DNA copies in a cancer cell. It suggests that a cell needs to establish harmony between these two genomes and provides potential implications for cancer treatments.

History

Principal supervisor

Justin Stjohn

Year of Award

2018

Department, School or Centre

Molecular and Translational Sciences

Campus location

Australia

Course

Doctor of Philosophy

Degree Type

DOCTORATE

Faculty

Faculty of Medicine Nursing and Health Sciences

Exports

Exports