Chris Yap_Masters thesis_2021_final revisions.pdf (1.17 MB)

The Effects of Clioquinol, Zinc and Copper on the Abundance and Function of Breast Cancer Resistance Protein in Human Brain Microvascular Endothelial Cells

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thesis
posted on 29.07.2021, 12:19 by CHRISTOPHER YUNG PHING YAP
This thesis examined the effects of clioquinol, zinc and copper on the function and expression of breast cancer resistance protein (BCRP) in human brain microvascular endothelial cells. The findings resulting from this research are the first to demonstrate the ability of BCRP abundance and function to be regulated by modulating cytosolic metal concentrations which may be exploited to influence the CNS passage of therapeutics and endogenous substrates.

History

Campus location

Australia

Principal supervisor

Joseph Anthony Nicolazzo

Additional supervisor 1

Dr Jennifer Short

Year of Award

2021

Department, School or Centre

Drug Delivery, Disposition and Dynamics

Additional Institution or Organisation

Faculty of Pharmacy and Pharmaceutical Sciences

Course

Master of Philosophy

Degree Type

MPHIL

Faculty

Faculty of Pharmacy and Pharmaceutical Sciences

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