The Effects of Clioquinol, Zinc and Copper on the Abundance and Function of Breast Cancer Resistance Protein in Human Brain Microvascular Endothelial Cells

This thesis examined the effects of clioquinol, zinc and copper on the function and expression of breast cancer resistance protein (BCRP) in human brain microvascular endothelial cells. The findings resulting from this research are the first to demonstrate the ability of BCRP abundance and function to be regulated by modulating cytosolic metal concentrations which may be exploited to influence the CNS passage of therapeutics and endogenous substrates.