Monash University

Restricted Access

Reason: Access restricted by the author. A copy can be requested for private research and study by contacting your institution's library service. This copy cannot be republished

The Comparative Effects of Endogenous, Synthetic and Selective Glucocorticoids during Lung Development

posted on 2018-07-20, 00:14 authored by BENNET KIM LEE SEOW
The studies presented in this thesis gains a better understanding of the molecular mechanisms behind steroid treatment of premature babies by characterising and comparing the different gene expressed in isolated lung cells treated with synthetic or normal steroids. Our findings suggest that synthetic steroids induce a stronger gene response for a large number of genes when compared to natural steroids. This unique gene signature is one that favours upregulated genes over repressed genes suggesting that steroid induced fetal lung development is more dependent on induced genes. This will ultimately lead to the development of new treatment approaches for premature babies


Principal supervisor

Timothy James Cole

Year of Award


Department, School or Centre

Biochemistry and Molecular Biology


Doctor of Philosophy

Degree Type



Faculty of Medicine Nursing and Health Sciences