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The Characterisation of Novel Pathways for the Induction of Mammalian Mitophagy

thesis
posted on 29.10.2020, 23:29 by WAI KIT LAM
Most cells in the human body are in a non-dividing state called quiescence. If quiescence does not function correctly, diseases such as fibrosis or cancer can develop. Inside cells, organelles called mitochondria supply energy. To remain healthy, mitochondria must go through disposal (called mitophagy) and renewal. This thesis discovers in quiescent cells, more mitochondria go through disposal than in dividing cells. It shows that mitophagy triggers renewal of mitochondria and helps quiescent cells to stay healthy. A new mechanism of mitophagy was identified. The findings ultimately could be used to develop drugs that prevent these quiescent cells from causing disease.

History

Principal supervisor

Georg Ramm

Additional supervisor 1

Mark Prescott

Year of Award

2020

Department, School or Centre

Biochemistry and Molecular Biology

Campus location

Australia

Course

Doctor of Philosophy

Degree Type

DOCTORATE

Faculty

Faculty of Medicine, Nursing and Health Sciences

Exports