The Cellular Lipid Landscape is a Defining Trait of Human and Murine Immune Systems

The cells of the immune system are diverse with specific effector functions. Their cellular identity is encoded by their transcriptomes, creating unique proteomes. If these identifying traits are seen with other cellular building blocks is unknown. Lipids are involved in numerous aspects of cell physiology. It is unknown if immune cells have unique lipidomes which contribute to their functions. In this thesis, lipidomic profiling was performed on cells from the human and murine immune systems, demonstrating cell- and lineage-specific differences. These findings provide the foundational framework to explore a new avenue of modulating immune cell function and potential immunomodulatory therapies.