The Anti-Allergic Effects of Kelulut Honey via the Regulation of Inflammatory Mediators of HMC-1 Cell

Activation and degranulation of mast cells cause the release of inflammatory mediators, resulting in the allergic symptoms. Kelulut honey (KH) is a Malaysian stingless bee honey that showed strong antioxidant and anti-inflammatory effects previously. Hence, this study investigates the potential anti-allergic effects of KH in activated human mast cell. The release of inflammatory mediators were inhibited by KH. High levels of polyphenols were detected in KH based on phytochemical profiling. The interaction of polyphenols in KH with signalling proteins were predicted using computational tools and the results showed that KH possibly possesses anti-inflammatory effects via MAPK signalling pathways.