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Reason: Under embargo until 21 June 2027. After this date a copy can be supplied under Section 51(2) of the Australian Copyright Act 1968 by submitting a document delivery request through your library
Targeting the cell of origin to prevent ER+ breast cancer
thesis
posted on 2024-06-21, 00:29 authored by MARIA LAMBOURASThe incidence of estrogen receptor positive (ER+) breast cancer continues to
increase and remains the most prevalent breast cancer subtype worldwide. To decrease breast cancer
cases, novel preventative therapies and preclinical models that phenocopy ER+ breast cancer
are needed. The cell of origin of ER+ BCa is a suggested drug target for breast cancer
prevention. This thesis analysed the mammary stem and progenitor epithelial cell
subsets that change upon ER+ breast cancer risk factor exposure to assist in identifying the cell
of origin of ER+ breast cancer which is thought to be the ER+ luminal progenitor (LP) cell subset.
