Tara E Scott_PhD Thesis_22591001_Final_with revisions.pdf (14.35 MB)

Targeting the NLRP3 inflammasome as a novel approach for the treatment of pulmonary hypertension

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thesis
posted on 10.11.2020, 04:35 by TARA ELIZABETH SCOTT
This thesis examined a new approach to treat high blood pressure in the lungs or ‘pulmonary hypertension’, a rare but incurable disease with limited treatment options. It determined that a component of the immune system, the ‘inflammasome’ is responsible for some of the damage associated with pulmonary hypertension, and that a new drug which selectively blocks the inflammasome can reverse established disease in experimental models. This exciting discovery offers new hope for the treatment of patients with pulmonary hypertension, and may improve their quality of life and survival.

History

Principal supervisor

Barbara Kemp

Additional supervisor 1

Adrian Hobbs

Additional supervisor 2

Grant Drummond

Year of Award

2020

Department, School or Centre

Pharmacology

Additional Institution or Organisation

William Harvey Research Institute, Queen Mary University of London, UK

Campus location

Australia

Course

Doctor of Philosophy

Degree Type

DOCTORATE

Exports

Categories

Exports