Targeting the Formyl Peptide Receptors Axis Regulates Physiological and Pathological Cardiovascular Damage

Current antihypertensive therapies lower blood pressure, but have limited efficacy in treating organ-damage. Pro-resolving mediators help control inflammation, a major cause of high blood pressure-related organ-damage. This thesis highlights that pro-resolving mediators improve heart and blood vessel function in both young and older, male and female mice. Interestingly, a lack of pro-resolving mediators leads to higher blood pressure and more severe organ-damage, especially in females. The research also finds that activating these pathways can reduce high blood pressure-related heart and vessel damage. These results suggest that pro-resolving therapies could be a new way to treat high blood pressure-associated complications.