Mingyu Zhu_PhD Thesis_final_2021.pdf (5.77 MB)
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Targeting CCL18 and its cognate receptor, CCR8 to treat hypertension-associated end-organ damage

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thesis
posted on 11.07.2021, 14:27 by MINGYU ZHU
High blood pressure is a highly prevalent disease, and many patients have uncontrolled blood pressure despite concurrent use of multiple medications (resistant hypertension). This thesis has found increased plasma levels of CCL18, a protein produced from human immune cells, in patients with resistant hypertension. CCL18 is also found to promote the blood vessel damage associated with high blood pressure. Therefore, CCL18 is identified as a potential indicator and treatment target for resistant hypertension.

History

Principal supervisor

Barbara Kemp

Additional supervisor 1

Grant Drummond

Year of Award

2021

Department, School or Centre

Pharmacology

Campus location

Australia

Course

Doctor of Philosophy

Degree Type

DOCTORATE

Faculty

Faculty of Medicine, Nursing and Health Sciences

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