Targeted Delivery of Small Interfering RNA (siRNA) Against Oncogenes by using pH-Sensitive Nanoparticles to Inhibit Breast Cancer Cells Proliferation and Survival

Harnessing siRNA technology has promising results in limiting the proliferation and survival of cancer cells by ‘silencing’ the expression of targeted genes. Carbonate apatite nanoparticle system has been employed to electrostatically complex with the siRNAs in order to prevent their degradation and renal clearance, and enhance the uptake by target cells following intravenous administration. This study would have significant impact in validating the potential applications of pH-sensitive carbonate apatite nanoparticles for delivery of siRNA cocktails in different models of breast cancer as well as in clinical trials.