Embargoed and Restricted Access
Reason: Under embargo until November 2024. After this date a copy can be supplied under Section 51(2) of the Australian Copyright Act 1968 by submitting a document delivery request through your library
Tailoring proteins as efficient binders for health and environmental applications
thesisposted on 2021-11-23, 20:25 authored by GINA PACHECO ARREDONDO
Molecular binders play important roles in biology and biotechnology. They are widely used in health, biomaterials and environmental sectors. Protein-based binders have attracted significant interest due to their desirable features like biocompatibility and their potential to be engineered for binding broad range molecule. While protein engineering is a powerful tool, it has not yet been fully exploited to improve functionalities of proteins as binders. Herein, this thesis explores tailoring proteins to suit a variety of different applications including the recovery of small molecules for environmental and diagnostic applications, removal of large and toxic molecules, or neutralization of viruses.