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Tackling Polymyxin Resistance in Pseudomonas aeruginosa: A Multi-disciplinary Approach

thesis
posted on 26.03.2018, 00:39 by MEILING HAN
This thesis, for the first time, provides an important mechanistic insight into the comprehensive mechanisms of polymyxin resistance in P. aeruginosa through the integrated neutron reflectometry and systems pharmacological approaches. Our research highlighted the complex and dynamic interactions of multiple cellular metabolic pathways involved in the bacterial physiological response to polymyxins, and their potential as therapeutic targets. Our study has made a significant contribution to understanding polymyxin mode of action and helps to tackle polymyxin resistance in Gram-negative "superbugs".

History

Campus location

Australia

Principal supervisor

Tony Velkov

Additional supervisor 1

Jian Li

Additional supervisor 2

Hsin-Hui Shen

Year of Award

2018

Department, School or Centre

Drug Delivery, Disposition and Dynamics

Course

Doctor of Philosophy

Degree Type

DOCTORATE

Faculty

Faculty of Pharmacy and Pharmaceutical Sciences

Exports