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T cell polarisation in the Preterm Infant and its Impact on Bronchopulmonary Dysplasia

thesis
posted on 03.09.2019, 05:12 by CHUN WANG JASON LAO
The chronic lung disease BPD is common in preterm babies, i.e. those born about two-thirds through a normal pregnancy. These babies are dependent on supplemental oxygen for months to years, and their doctors have no effective therapy. I examined blood samples from 51 preterm babies at birth and 4 other time points and found that BPD babies have specific immune polarisation patterns. This finding provides a new understanding of the process driving BPD and lays the foundation for repurposing of a group of existing medicines for use in these tiny patients, bringing hope for relief from this devastating disease.

History

Principal supervisor

Marcel Nold

Additional supervisor 1

Claudia Nold

Additional supervisor 2

Ina Rudloff

Additional supervisor 3

Niamh Mangan

Year of Award

2019

Department, School or Centre

Paediatrics

Additional Institution or Organisation

Hudson Institute of Medical Research

Campus location

Australia

Course

Doctor of Philosophy

Degree Type

DOCTORATE

Exports

Exports