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THE EFFECTS OF MITOCHONDRIAL DNA ON PORCINE PREIMPLANTATION EMBRYO DEVELOPMENT
thesisposted on 2017-11-07, 23:04 authored by TE-SHA TSAI
The overall aim of my thesis was to determine the role of mitochondrial DNA (mtDNA) during porcine oocyte maturation and preimplantation embryo development. We have found that mtDNA affects oocyte quality and litter sizes. Using the pig model, we have developed a method to identify oocytes that are deficient in mtDNA. To increase mtDNA, we supplemented those oocytes with a pure population of mitochondria at the time of in vitro fertilisation, to deliver good quality mtDNA, for the improvement of oocyte quality. The outcomes of my work are applicable to farm animal production and assisted reproduction in the clinic.