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THE EFFECTS OF MITOCHONDRIAL DNA ON PORCINE PREIMPLANTATION EMBRYO DEVELOPMENT

thesis
posted on 07.11.2017, 23:04 authored by TE-SHA TSAI
The overall aim of my thesis was to determine the role of mitochondrial DNA (mtDNA) during porcine oocyte maturation and preimplantation embryo development. We have found that mtDNA affects oocyte quality and litter sizes. Using the pig model, we have developed a method to identify oocytes that are deficient in mtDNA. To increase mtDNA, we supplemented those oocytes with a pure population of mitochondria at the time of in vitro fertilisation, to deliver good quality mtDNA, for the improvement of oocyte quality. The outcomes of my work are applicable to farm animal production and assisted reproduction in the clinic.

History

Principal supervisor

Justin Stjohn

Additional supervisor 1

Matthew McKenzie

Year of Award

2017

Department, School or Centre

Molecular and Translational Sciences

Additional Institution or Organisation

Hudson Institute of Medical Research

Campus location

Australia

Course

Doctor of Philosophy

Degree Type

DOCTORATE

Faculty

Faculty of Medicine Nursing and Health Sciences