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Reason: Under embargo until November 2020. After this date a copy can be supplied under Section 51 (2) of the Australian Copyright Act 1968 by submitting a document delivery request through your library

THE EFFECTS OF MITOCHONDRIAL DNA ON PORCINE PREIMPLANTATION EMBRYO DEVELOPMENT

thesis
posted on 2017-11-07, 23:04 authored by TE-SHA TSAI
The overall aim of my thesis was to determine the role of mitochondrial DNA (mtDNA) during porcine oocyte maturation and preimplantation embryo development. We have found that mtDNA affects oocyte quality and litter sizes. Using the pig model, we have developed a method to identify oocytes that are deficient in mtDNA. To increase mtDNA, we supplemented those oocytes with a pure population of mitochondria at the time of in vitro fertilisation, to deliver good quality mtDNA, for the improvement of oocyte quality. The outcomes of my work are applicable to farm animal production and assisted reproduction in the clinic.

History

Principal supervisor

Justin Stjohn

Additional supervisor 1

Matthew McKenzie

Year of Award

2017

Department, School or Centre

Central Clinical School

Additional Institution or Organisation

Molecular and Translational Science (Hudson Institute)

Campus location

Australia

Course

Doctor of Philosophy

Degree Type

DOCTORATE

Faculty

Faculty of Medicine Nursing and Health Sciences

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    Faculty of Medicine, Nursing and Health Sciences Theses

    Categories

    Keywords

    Mitochondrial DNAEmbryo DevelopmentAssisted Reproductive TechnologyPorcine ModelAnimal Developmental and Reproductive Biology

    Licence

    In Copyright

    Exports