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Reason: Under embargo until November 2020. After this date a copy can be supplied under Section 51 (2) of the Australian Copyright Act 1968 by submitting a document delivery request through your library
THE EFFECTS OF MITOCHONDRIAL DNA ON PORCINE PREIMPLANTATION EMBRYO DEVELOPMENT
thesis
posted on 2017-11-07, 23:04 authored by TE-SHA TSAIThe overall aim of my thesis was to determine the role of mitochondrial DNA (mtDNA) during porcine oocyte maturation and preimplantation embryo development. We have found that mtDNA affects oocyte quality and litter sizes. Using the pig model, we have developed a method to identify oocytes that are deficient in mtDNA. To increase mtDNA, we supplemented those oocytes with a pure population of mitochondria at the time of in vitro fertilisation, to deliver good quality mtDNA, for the improvement of oocyte quality. The outcomes of my work are applicable to farm animal production and assisted reproduction in the clinic.