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THE BIOLOGICAL AND PHYSIOLOGICAL IMPACT OF THE REMOVAL OF MIDDLE MOLECULES USING A NEW TYPE OF POLYETHERSULFONE HIGH CUT-OFF MEMBRANE DURING BLOOD PURIFICATION

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thesis
posted on 02.04.2019, 03:10 by RAFIDAH ATAN
An excess of inflammatory substances, i.e. cytokines, in the body is believed to contribute to poor outcomes in critically ill patients. Various strategies to reduce the levels of these harmful substances have been studied including the use of high cut-off kidney filters. This thesis examines the above theory; first through an extensive search of previous studies on all cytokine removal techniques. We then report the findings of our research project on the clinical effects of the high cut-off filters, as well as its effects on various mediators and biomarkers in severe critical illness with acute kidney failure.

History

Principal supervisor

Anuar Zaini

Additional supervisor 1

Rinaldo Bellomo

Year of Award

2018

Department, School or Centre

Jeffrey Cheah School of Medicine and Health Sciences (Monash University Malaysia)

Additional Institution or Organisation

Austin Health

Campus location

Malaysia

Course

Doctor of Philosophy

Degree Type

DOCTORATE

Faculty

Faculty of Medicine Nursing and Health Sciences