TESTICULAR NEOPLASIA: FUNCTIONAL POLARIZATION OF MACROPHAGES AND DENDRITIC CELLS

Testicular germ cell tumours (TGCTs) are most frequently associated with immune cell infiltrations that include macrophages and DCs. Macrophages and DCs can be involved in tumour progression and tumour destruction. Thus, a characterisation of macrophages and DC subsets that are associated with pathological alterations such as testicular neoplasia was conducted. Additionally, we investigated how tumour cells modulate immune cell responses. In conclusion, it is important to understand how immune cells, which serve an immune-protective role in the healthy testis, may contribute to the emergence or progression of TGCTs using strategies that reflect their diversity and functional flexibility.