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Systems Pharmacology of Polymyxins and Their Synergistic Combinations against Acinetobacter baumannii

thesis
posted on 07.07.2021, 06:41 by Jinxin Zhao
This thesis targets a significant global medical challenge, antimicrobial resistance. Cutting-edge systems pharmacology approaches were employed to elucidate the mechanisms of antibiotic resistance and synergistic killing of life-saving polymyxin-based combinations in multidrug-resistant Acinetobacter baumannii. This work provides critical pharmacological information for optimisation of dosage regimens of polymyxins and their combinations in patients.

History

Principal supervisor

Jian Li

Year of Award

2021

Department, School or Centre

Microbiology

Course

Doctor of Philosophy

Degree Type

DOCTORATE

Faculty

Faculty of Medicine, Nursing and Health Sciences

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