Systemic Inflammation after Paediatric Traumatic Brain Injury: Consequences for Acute and Chronic Outcomes

Paediatric traumatic brain injury (TBI) is a major public health-issue and a risk factor for the development of neurodegenerative conditions such as post-traumatic epilepsy. However, how PTE develops after TBI remains unclear. Working with a paediatric mouse model of experimental TBI, this PhD project investigated the relationship between brain injury, peripheral infection, and the neuroinflammatory response, with a focus on secondary injury outcomes including epilepsy. Altogether, knowledge acquired from this thesis provides a foundation for future research to identify key inflammatory mediators and their precise biomolecular pathways involved in TBI pathology as potential therapeutic targets.