Synthetic Routes to Bioactive Heterocycles - Studies toward the frameworks of zaragozic acids and polyandrocarpamide D

Zaragozic acids (ZAs) are a family of fungal natural products exhibiting strong inhibition of squalene synthase (SS), the first enzyme involved in the synthesis of cholesterol. This thesis examined new synthetic approaches to construct the framework of ZAs and the marine-derived thermochromic heterocycle polyandrocarpamide D.