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Synthesis of fatty acid-terminated polymers by copper-mediated polymerization for drug delivery applications
thesisposted on 09.01.2021, 23:37 by ALEXANDER MOERSDORF
A library of lipid-terminated ATRP-initiators and polymers based on PEG were synthesized. The self-assembly of the amphiphilic PEG-polymers was studied, as well as their binding to bovine serum albumin. Cytotoxic studies and pharmacokinetics proved their capability to serve as drug delivery devices after binding to albumin.