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Synthesis of fatty acid-terminated polymers by copper-mediated polymerization for drug delivery applications

thesis
posted on 09.01.2021, 23:37 authored by ALEXANDER MOERSDORF
A library of lipid-terminated ATRP-initiators and polymers based on PEG were synthesized. The self-assembly of the amphiphilic PEG-polymers was studied, as well as their binding to bovine serum albumin. Cytotoxic studies and pharmacokinetics proved their capability to serve as drug delivery devices after binding to albumin.

History

Principal supervisor

John F Quinn

Additional supervisor 1

Mikey Whittaker

Year of Award

2021

Department, School or Centre

Drug Delivery, Disposition and Dynamics

Course

Doctor of Philosophy

Degree Type

DOCTORATE

Faculty

Faculty of Pharmacy and Pharmaceutical Sciences