Thesis Matthew Wakeham Final.pdf (6.51 MB)
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Synthesis and pharmacological investigation of hybrid ligands targeting the muscarinic acetylcholine receptors

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posted on 16.04.2020, 00:35 authored by MATTHEW CHARLES LINFORD WAKEHAM
In this thesis we explore a novel series of molecules designed to target multiple binding sites of the muscarinic acetylcholine receptors, in terms of their chemical structure and molecular mechanism. Herein we have developed many tool molecules which will further aid in the understanding and development of selective drugs for the treatment of cognitive disorders such as schizophrenia and Alzheimer's disease.


Campus location


Principal supervisor

Peter Scammells

Additional supervisor 1

Ben Capuano

Year of Award


Department, School or Centre

Medicinal Chemistry

Additional Institution or Organisation

Monash Institute of Pharmaceutical Sciences


Doctor of Philosophy

Degree Type