Thesis Matthew Wakeham Final.pdf (6.51 MB)
Synthesis and pharmacological investigation of hybrid ligands targeting the muscarinic acetylcholine receptors
thesisposted on 2020-04-16, 00:35 authored by MATTHEW CHARLES LINFORD WAKEHAM
In this thesis we explore a novel series of molecules designed to target multiple binding sites of the muscarinic acetylcholine receptors, in terms of their chemical structure and molecular mechanism. Herein we have developed many tool molecules which will further aid in the understanding and development of selective drugs for the treatment of cognitive disorders such as schizophrenia and Alzheimer's disease.