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Synthesis and Biological Evaluation of Pyrazolo[3,4-d]pyrimidine and Their Fused Analogues as Potential Anticancer Agents
thesisposted on 2023-06-21, 06:19 authored by JIA HUI NG
The thesis is focused on preparing pyrazolopyrimidines structurally similar to biogenic purines and evaluating their anticancer properties. The fused heterocyclic systems related to the pyrazolopyrimidine skeleton also fall within the area of the thesis's interest. Several new efficient methods for the preparation of these compounds were developed. More than 150 novel compounds were prepared and studied. Some promising antileukemic compounds were identified.