Monash University

Embargoed and Restricted Access

Reason: Under embargo until November 2022. After this date a copy can be supplied under Section 51(2) of the Australian Copyright Act 1968 by submitting a document delivery request through your library

Synthesis and Biological Evaluation of 1,2,4-Triazolo[1,5-a][1,3,5]triazines Inducing Apoptosis in Leukemic Cells

posted on 2019-11-29, 15:21 authored by KOON KEE KOW
The thesis focuses on the development of new and safe therapeutic agents against leukemia. A new class of highly potent compounds selectively inhibiting growth of leukemic cells, without any observable harm to normal cells, was discovered. Initially, a series of the compounds was prepared and tested to build a structure-activity relationship model. This model was used to design molecules with a greater antileukemic potential. These compounds were prepared and explored. Being two orders more potent in the inhibition of leukemic cell growth that modern chemotherapeutic medicines, these compounds demonstrated a promising profile for the further development as future therapeutic agents.


Campus location


Principal supervisor

Anton Dolzhenko

Additional supervisor 1

Lim Su Wen

Year of Award


Department, School or Centre

School of Pharmacy (Malaysia)


Doctor of Philosophy

Degree Type



Faculty of Pharmacy and Pharmaceutical Sciences